8 Oct 2007 Our DNA is packaged in chromosomes, which occur in pairs – one Smithies initially tried to repair mutated genes in human cells. Embryonic stem cells – vehicles to the mouse germ line It is now possible to introd

Glioma stem-like cells (GSCs) are recognized as a special population of GBM cells that contributes to tumorigenesis, radiochemoresistance, and recurrence [6-9]. Developing new therapeutic drugs combined with conventional therapy is strongly needed for GBM patients.

Glioblastoma multiforme (GBM) is an aggressive brain tumor that is resistant to all known therapies. Within these tumors, a CD133-positive cancer-initiating neural stem cell (NSC) population was shown to be resistant to gamma radiation through preferential activation of the DNA double-strand break (DSB) response machinery, including the ataxia-telangiectasia-mutated (ATM) kinase. Notch Pathway Does Not Alter DNA Damage Response of Glioma Stem Cells The DNA damage checkpoint response plays a critical role in cellular response to radiation [ 48 , 49 ]. Our previous study showed that increased activation of the DNA damage response is implicated in radioresistance of the glioma stem cells [ 7 ].

Glioma stem cells promote radioresistance by preferential activation of the dna damage response

The fraction of tumour cells expressing CD133 (Prominin-1),… Cancer stem cells contribute to glioma radioresistance by an increase of DNA repair capacity through preferential activation of the DNA damage response checkpoints. Potential therapies that modulate or target cancer stem cells are also reviewed. 2006-12-01 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Author(s): Shideng Bao , Qiulian Wu , Roger E. McLendon , Yueling Hao , Qing Shi , Anita B. Hjelmeland , Mark W. Dewhirst , Darell D. Bigner , Jeremy N. Rich Glioma stem cells promote radioresistance by preferential activation of the DNA damage response 2021-03-09 · Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells3,4,5,6, is enriched after radiation in gliomas. cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity.

cells glioma cells, VRP in drug-resistant tumors and dexamethasone of hematopoietic stem cells, and activated Notch receptors chemotherapy‑induced DNA damage in a nitric oxide (NO).

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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. 2019-08-27 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature , 444 ( 2006 ) , pp. 756 - 760 CrossRef View Record in Scopus Google Scholar Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Shideng Bao, et al., Nature, 444:756 (2006) Speaker : non-stem glioma cells due to preferential activation of the DNA damage response pathway [7].

Here we show that short-term cultures of glioma xenografts subjected to three serial cancer stem cells contribute to glioma radioresistance through cycles of IR also contained greater percentages of CD1331 cells than preferential activation of the DNA damage checkpoint response parental populations (Supplementary Fig. S2).

The fraction of tumour Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN. Nature. 2006 Dec 7;444(7120):756-60. Epub 2006 Oct 18. PMID 17051156 : Anaplastic oligodendroglioma. Blakeley J, Grossman S. Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation.

Nature. 2006; 444 (7120):756–760. They concluded that CD133 + cells can activate DNA damage checkpoint responses to a greater degree than CD133 − cells and thus repair DNA damage more efficiently. Intriguingly, by using an inhibitor of the checkpoint kinases Chk1 and Chk2, they were able to radiosensitize the CD133 + cells. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Autores: Shideng Bao, Qing Shi, Yueling Hao, Roger E. McLendon, Darell D. Bigner, Qiulian Wu, Anita B. Hjelmeland, Jeremy N. Rich, Mark W. Dewhirst Add your e-mail address to receive free newsletters from SCIRP.
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The sign of radioresistance was the accumulation of The mechanisms underlying tumour radioresistance have remained elusive. Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas. In both cell culture and the brains of immunocompromised mice, CD133-expressing glioma cells survive ionizing radiation in increased proportions Here we show that cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas.

444, 756-760 (2006). Singh, S. K., et al. Analysen är baserad på stamcells differentiering reporter varvid uttrycket av den förbättrade GFP Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.
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Glioma stem cells promote radioresistance by preferential activation of the dna damage response

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In response to DNA damage, normal cells activate the DNA damage response (DDR), utilizing a variety of DNA damage sensing and repair pathways (e.g., base excision repair, nucleotide excision repair, homologous recombination, nonhomologous end-joining, mis-match repair, direct reversal) to maintain genomic integrity, whereas the inability to

The fraction of tumour cells expressing CD133 (Prominin-1), a marker for both neural stem cells and brain cancer stem cells, is enriched after radiation in gliomas. Ionizing radiation represents the most effective therapy for glioblastoma (World Health Organization grade IV glioma), one of the most lethal human malignancies, but radiotherapy remains only palliative because of radioresistance.

Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006; 444 : 756–760. CAS Article Google Scholar

These effects were abolished by exogenous miR-603 expression, suggesting potential for clinical translation. 2019-02-05 · Glioma stem cells promote radioresistance by preferential activation of the DNA damage response Nature , 444 ( 2006 ) , pp.

cancer stem cells contribute to glioma radioresistance through preferential activation of the DNA damage checkpoint response and an increase in DNA repair capacity. The fraction of tumour Notch inhibition with GSIs did not alter the DNA damage response of glioma stem cells following radiation, but rather impaired radiation-induced Akt activation and upregulated levels of the truncated apoptotic isoform of Mcl-1 (Mcl-1s). Taken together, our results suggest a critical role of Notch to promote radioresistance of glioma stem cells.